One of the most significant aspects of this planetary alignment, is not only that Mercury is in one of its own signs but it is all happening right at the heart of the galactic centre. Also known as the Milky Way, and to me this is even more significant than the fact that all these planets will be opposing Pluto. Although it is an important aspect to keep in mind as well, it is not nearly as mind blowing to see. Since Pluto doesn't even come up on the radar any more in our galaxy, the actual real change that is going to be influencing the collective will probably be more due to the fact of this grand scale configuration. Where the ecliptic and the centre meet, this also occurred when we entered it back at the end of December 2012.
So this would be a perfect time to reflect on what kind of transformations occurred at that time. If not physically than from spiritual standpoint.
As the moon will be in the sign of the twin, this new cycle will include a lot more self reflecting as we continue to develop into renewed avenues of living. As with the North node in Virgo, also ruled by Mercury. In most cases it will be in the best and also most healthy way possible.
As long as you don't get too overwhelmed by the excitement of all the new possibilities, this is going to be most enjoyable.